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Alexander Arrington, ND
A 7-year-old male experienced complete remission of severe anxiety and obsessive-compulsive behaviors following targeted microbiome and nutritional therapy.
A 7-year-old male presented with sudden-onset severe anxiety and obsessive-compulsive behaviors, including excessive hand washing and heightened sensitivity to sensory stimuli. Initial interventions included supplementation with a Bacillus spp probiotic and omega-3 fatty acids. Over four months, the patient exhibited significant improvement, culminating in the resolution of anxiety and obsessive-compulsive tendencies. This case underscores the potential role of gut microbiota modulation2-4 and omega-3 supplementation1 in managing pediatric anxiety disorders.
Anxiety and obsessive-compulsive disorder (OCD)-like behaviors in children pose significant treatment challenges. Emerging research highlights the gut-brain axis as a critical pathway influencing mood and behavior.3 Probiotics, particularly those containing Bacillus species, and omega-3 fatty acids have shown promise in modulating this axis to alleviate neuropsychiatric symptoms.1-4 This case report details the resolution of severe anxiety and OCD-like behaviors in a pediatric patient following targeted probiotic and omega-3 supplementation.
A 7-year-old male was brought in by his mother on October 27 with concerns about sudden-onset severe anxiety. The patient had a history of constipation, allergies managed with Claritin and occasional Flonase, reflux, and occasional vomiting. He had been described as a clingy infant who cried when people looked at him.
The patient exhibited compulsive hand-washing, refusal to touch objects without fresh towels, and heightened sensitivity to smells, particularly his grandmother’s shampoo scent. He displayed intense distress when his brother ate buttery foods, fearing contamination, and expressed irrational fears of death, both his own and his mother’s.
Timeline:
– October 27: Initial consultation. Recommended probiotic supplementation; the product had not yet arrived.
– October 28: The patient responded positively to a chewable probiotic containing Bacillus spp. His mother also ordered a tasteless powder mix as a backup.
– October 29: Advised to administer probiotics with meals.
– October 31: Noted slight daily improvements, including self-feeding and reduced emotional breakdowns over sticky candy.
– November 9: New stressors emerged, including anxiety about numerical imbalances and contamination fears. Despite this, the patient exhibited more rational responses and could be talked through anxious moments.
– February 11: Significant progress observed. The patient revisited a previously anxiety-inducing store without distress and remained calm after spilling orange juice on himself.
1. Obsessive-Compulsive Disorder (OCD): Considered due to the presence of compulsive behaviors; however, the sudden onset and absence of persistent intrusive thoughts suggested an alternative diagnosis.
2. Pediatric Acute-onset Neuropsychiatric Syndrome (PANS): The abrupt onset of severe anxiety and OCD-like behaviors, coupled with a recent mild fever, raised the possibility of PANS. However, the lack of definitive infectious or neurological markers made this diagnosis inconclusive.
3. Sensory Processing Disorder: The patient’s heightened sensitivity to sensory stimuli aligned with this disorder; however, the concurrent anxiety and compulsive behaviors indicated a broader neuropsychiatric condition.
Probiotic Supplementation:
– Product: Chewable probiotic containing Bacillus spp.
– Dosage: 1 tablet daily.
– Rationale: Bacillus species are spore-forming probiotics known for their resilience and ability to modulate the gut microbiome.3,4 They have been associated with improved gastrointestinal health and potential benefits in reducing anxiety symptoms through the gut-brain axis.2,4
Omega-3 Supplementation:
– Product: Chewable omega-3 fatty acid supplement.
– Composition: Total Omega-3s: 63 mg; EPA and DHA: 51 mg.
– Dosage: 1 chewable daily.
– Rationale: Omega-3 fatty acids, particularly EPA and DHA, are essential for neurological development and function. They have demonstrated efficacy in reducing inflammation and have been linked to improvements in mood and anxiety disorders.1
Over four months, the patient exhibited progressive improvements in anxiety and compulsive behaviors. By February 11, he demonstrated complete resolution of these symptoms, engaging in previously distressing situations without anxiety. His mother attributed this significant change to the introduction of probiotics and omega-3 supplementation, suggesting a potential role for these interventions in modulating neuropsychiatric symptoms.
The gut-brain axis represents a complex communication network linking the gastrointestinal tract and the central nervous system. Modulating this axis through probiotics and omega-3 fatty acids has garnered attention for its potential in managing neuropsychiatric disorders. 3,4
Human clinical trials have shown that Bacillus species such as B. coagulans can reduce symptoms of depression and improve mood. While the precise mechanisms remain under investigation, proposed pathways include modulation of the gut-brain axis, anti-inflammatory signaling, and possible influence on neurotransmitters such as GABA and serotonin.4
Omega-3 fatty acids, particularly EPA and DHA, are integral to neuronal membrane fluidity and function. In a randomized, double-blind, placebo-controlled trial by Kiecolt-Glaser et al. (2011), omega-3 supplementation reduced anxiety in young adults1, reinforcing its potential as an adjunct therapy in pediatric mental health care.
In this case, the combined use of Bacillus spp. probiotics and omega-3s may have provided synergistic benefits by enhancing gut microbiota composition3,4 and reducing systemic inflammation.1 This integrative approach highlights the need for holistic, naturopathic strategies in the management of pediatric anxiety disorders.
The patient’s mother expressed profound relief and gratitude, noting her son’s remarkable transformation. She highlighted his newfound ability to engage in daily activities without anxiety, emphasizing the positive impact on their family’s quality of life.
This case illustrates the potential therapeutic value of Bacillus spp. probiotics and chewable omega-3 fatty acids in addressing severe anxiety and OCD-like symptoms in children.1-4 The profound behavioral improvements suggest a viable role for microbiome and inflammation-focused interventions in pediatric mental health care. As research continues to unravel the mechanisms of the gut-brain axis, naturopathic strategies that leverage gut modulation and nutritional therapy may offer significant clinical value for anxiety and related neuropsychiatric conditions in young patients.2-4
Dr. Alexander Arrington, born in the Ohio River Valley, earned a Bachelor of Science in microbiology from the University of Akron and a doctorate in naturopathic medicine from the National University of Natural Medicine in Portland, Oregon. A licensed naturopathic physician in the District of Columbia since 2021, Dr. Arrington focuses on providing individualized care, incorporating nutritional, botanical, physical, and behavioral approaches to help patients achieve their health goals. He also previously served as an adjunct professor of Microbiology and Microbial Genetics at Marshall University. Outside of his medical practice, Dr. Arrington enjoys rock climbing, martial arts, and playing music.
1. Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011;25(8):1725-1734.
2. Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR, et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Nutrition. 2016;32(3):315-320.
3. Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr. 2019;10(suppl_1):S49–S66.4. Majeed M, Nagabhushanam K, Natarajan S, et al. A randomized, double-blind, placebo-controlled trial of the probiotic Bacillus coagulans MTCC 5856 in patients with major depressive disorder. J Probiotics Health. 2018;6(1):1–6. doi:10.4172/2329-8901.1000190
Alexander Arrington, ND
A 7-year-old male experienced complete remission of severe anxiety and obsessive-compulsive behaviors following targeted microbiome and nutritional therapy.
A 7-year-old male presented with sudden-onset severe anxiety and obsessive-compulsive behaviors, including excessive hand washing and heightened sensitivity to sensory stimuli. Initial interventions included supplementation with a Bacillus spp probiotic and omega-3 fatty acids. Over four months, the patient exhibited significant improvement, culminating in the resolution of anxiety and obsessive-compulsive tendencies. This case underscores the potential role of gut microbiota modulation2-4 and omega-3 supplementation1 in managing pediatric anxiety disorders.
Anxiety and obsessive-compulsive disorder (OCD)-like behaviors in children pose significant treatment challenges. Emerging research highlights the gut-brain axis as a critical pathway influencing mood and behavior.3 Probiotics, particularly those containing Bacillus species, and omega-3 fatty acids have shown promise in modulating this axis to alleviate neuropsychiatric symptoms.1-4 This case report details the resolution of severe anxiety and OCD-like behaviors in a pediatric patient following targeted probiotic and omega-3 supplementation.
A 7-year-old male was brought in by his mother on October 27 with concerns about sudden-onset severe anxiety. The patient had a history of constipation, allergies managed with Claritin and occasional Flonase, reflux, and occasional vomiting. He had been described as a clingy infant who cried when people looked at him.
The patient exhibited compulsive hand-washing, refusal to touch objects without fresh towels, and heightened sensitivity to smells, particularly his grandmother’s shampoo scent. He displayed intense distress when his brother ate buttery foods, fearing contamination, and expressed irrational fears of death, both his own and his mother’s.
Timeline:
– October 27: Initial consultation. Recommended probiotic supplementation; the product had not yet arrived.
– October 28: The patient responded positively to a chewable probiotic containing Bacillus spp. His mother also ordered a tasteless powder mix as a backup.
– October 29: Advised to administer probiotics with meals.
– October 31: Noted slight daily improvements, including self-feeding and reduced emotional breakdowns over sticky candy.
– November 9: New stressors emerged, including anxiety about numerical imbalances and contamination fears. Despite this, the patient exhibited more rational responses and could be talked through anxious moments.
– February 11: Significant progress observed. The patient revisited a previously anxiety-inducing store without distress and remained calm after spilling orange juice on himself.
1. Obsessive-Compulsive Disorder (OCD): Considered due to the presence of compulsive behaviors; however, the sudden onset and absence of persistent intrusive thoughts suggested an alternative diagnosis.
2. Pediatric Acute-onset Neuropsychiatric Syndrome (PANS): The abrupt onset of severe anxiety and OCD-like behaviors, coupled with a recent mild fever, raised the possibility of PANS. However, the lack of definitive infectious or neurological markers made this diagnosis inconclusive.
3. Sensory Processing Disorder: The patient’s heightened sensitivity to sensory stimuli aligned with this disorder; however, the concurrent anxiety and compulsive behaviors indicated a broader neuropsychiatric condition.
Probiotic Supplementation:
– Product: Chewable probiotic containing Bacillus spp.
– Dosage: 1 tablet daily.
– Rationale: Bacillus species are spore-forming probiotics known for their resilience and ability to modulate the gut microbiome.3,4 They have been associated with improved gastrointestinal health and potential benefits in reducing anxiety symptoms through the gut-brain axis.2,4
Omega-3 Supplementation:
– Product: Chewable omega-3 fatty acid supplement.
– Composition: Total Omega-3s: 63 mg; EPA and DHA: 51 mg.
– Dosage: 1 chewable daily.
– Rationale: Omega-3 fatty acids, particularly EPA and DHA, are essential for neurological development and function. They have demonstrated efficacy in reducing inflammation and have been linked to improvements in mood and anxiety disorders.1
Over four months, the patient exhibited progressive improvements in anxiety and compulsive behaviors. By February 11, he demonstrated complete resolution of these symptoms, engaging in previously distressing situations without anxiety. His mother attributed this significant change to the introduction of probiotics and omega-3 supplementation, suggesting a potential role for these interventions in modulating neuropsychiatric symptoms.
The gut-brain axis represents a complex communication network linking the gastrointestinal tract and the central nervous system. Modulating this axis through probiotics and omega-3 fatty acids has garnered attention for its potential in managing neuropsychiatric disorders. 3,4
Human clinical trials have shown that Bacillus species such as B. coagulans can reduce symptoms of depression and improve mood. While the precise mechanisms remain under investigation, proposed pathways include modulation of the gut-brain axis, anti-inflammatory signaling, and possible influence on neurotransmitters such as GABA and serotonin.4
Omega-3 fatty acids, particularly EPA and DHA, are integral to neuronal membrane fluidity and function. In a randomized, double-blind, placebo-controlled trial by Kiecolt-Glaser et al. (2011), omega-3 supplementation reduced anxiety in young adults1, reinforcing its potential as an adjunct therapy in pediatric mental health care.
In this case, the combined use of Bacillus spp. probiotics and omega-3s may have provided synergistic benefits by enhancing gut microbiota composition3,4 and reducing systemic inflammation.1 This integrative approach highlights the need for holistic, naturopathic strategies in the management of pediatric anxiety disorders.
The patient’s mother expressed profound relief and gratitude, noting her son’s remarkable transformation. She highlighted his newfound ability to engage in daily activities without anxiety, emphasizing the positive impact on their family’s quality of life.
This case illustrates the potential therapeutic value of Bacillus spp. probiotics and chewable omega-3 fatty acids in addressing severe anxiety and OCD-like symptoms in children.1-4 The profound behavioral improvements suggest a viable role for microbiome and inflammation-focused interventions in pediatric mental health care. As research continues to unravel the mechanisms of the gut-brain axis, naturopathic strategies that leverage gut modulation and nutritional therapy may offer significant clinical value for anxiety and related neuropsychiatric conditions in young patients.2-4
Dr. Alexander Arrington, born in the Ohio River Valley, earned a Bachelor of Science in microbiology from the University of Akron and a doctorate in naturopathic medicine from the National University of Natural Medicine in Portland, Oregon. A licensed naturopathic physician in the District of Columbia since 2021, Dr. Arrington focuses on providing individualized care, incorporating nutritional, botanical, physical, and behavioral approaches to help patients achieve their health goals. He also previously served as an adjunct professor of Microbiology and Microbial Genetics at Marshall University. Outside of his medical practice, Dr. Arrington enjoys rock climbing, martial arts, and playing music.
1. Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011;25(8):1725-1734.
2. Akbari E, Asemi Z, Daneshvar Kakhaki R, Bahmani F, Kouchaki E, Tamtaji OR, et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Nutrition. 2016;32(3):315-320.
3. Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr. 2019;10(suppl_1):S49–S66.4. Majeed M, Nagabhushanam K, Natarajan S, et al. A randomized, double-blind, placebo-controlled trial of the probiotic Bacillus coagulans MTCC 5856 in patients with major depressive disorder. J Probiotics Health. 2018;6(1):1–6. doi:10.4172/2329-8901.1000190
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The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making
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It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution
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