/ Nov 05, 2025
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Neuroprotection…from Grandma?

Pregnant women know not to smoke, but do they know they should eat apples and basil, oregano, rosemary, sage, and thyme? Not just for their own health, or their unborn’s health, but also for their grandchild’s health. 

While investigating brain nerve cells, which communicate and connect through axons–about 850,000 kilometers worth of them–senior author Professor Roger Pocock and his team at the Monash Biomedicine Discovery Institute in Australia questioned:

  • How to explore maternal provisioning to offspring, and multigenerational inheritance 
  • Can natural products might stabilize axons to lessen or prevent breakage
  • How the natural plant product ursolic acid provides neuroprotection, reducing the fragility of axons

In the study, published in Nature CellBiology, researchers state:

  • “feeding Caenorhabditis elegans [roundworm] with ursolic acid…improves axon transport and reduces adult-onset axon fragility intergenerationally”
  • “Ursolic acid provides neuroprotection by enhancing maternal provisioning of sphingosine-1-phosphate, a bioactive sphingolipid”
  • “Intestine-to-oocyte sphingosine-1-phosphate transfer is required for intergenerational neuroprotection and is dependent on the RME-2 lipoprotein yolk receptor.”

They conclude that “our study reveals that a short-term dietary supplement during the maternal reproductive period can be neuroprotective over multiple generations—providing a paradigm for intergenerational inheritance of health-promoting traits. We propose that intergenerational regulation of metabolism and metabolic gene expression is a universal principle underlying intergenerational inheritance across evolution.” Results will need to be confirmed in humans.

Pregnant women know not to smoke, but do they know they should eat apples and basil, oregano, rosemary, sage, and thyme? Not just for their own health, or their unborn’s health, but also for their grandchild’s health. 

While investigating brain nerve cells, which communicate and connect through axons–about 850,000 kilometers worth of them–senior author Professor Roger Pocock and his team at the Monash Biomedicine Discovery Institute in Australia questioned:

  • How to explore maternal provisioning to offspring, and multigenerational inheritance 
  • Can natural products might stabilize axons to lessen or prevent breakage
  • How the natural plant product ursolic acid provides neuroprotection, reducing the fragility of axons

In the study, published in Nature CellBiology, researchers state:

  • “feeding Caenorhabditis elegans [roundworm] with ursolic acid…improves axon transport and reduces adult-onset axon fragility intergenerationally”
  • “Ursolic acid provides neuroprotection by enhancing maternal provisioning of sphingosine-1-phosphate, a bioactive sphingolipid”
  • “Intestine-to-oocyte sphingosine-1-phosphate transfer is required for intergenerational neuroprotection and is dependent on the RME-2 lipoprotein yolk receptor.”

They conclude that “our study reveals that a short-term dietary supplement during the maternal reproductive period can be neuroprotective over multiple generations—providing a paradigm for intergenerational inheritance of health-promoting traits. We propose that intergenerational regulation of metabolism and metabolic gene expression is a universal principle underlying intergenerational inheritance across evolution.” Results will need to be confirmed in humans.

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It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy.

The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making

The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using ‘Content here, content here’, making it look like readable English. Many desktop publishing packages and web page editors now use Lorem Ipsum as their default model text, and a search for ‘lorem ipsum’ will uncover many web sites still in their infancy.

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It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution

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